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Jay Yadav, MD

Chief Investment Officer (CIO) and Operating Manager

How Jay Drives Value to the Funds,
Founders, and Investors

As one of Mammoth’s venture capital investment decision makers, Dr. Yadav has a long history of innovation which has improved the treatment of major public health problems such as heart failure and stroke. Companies under Jay’s leadership have created over $1 billion in shareholder value:

Career Highlights

    • Founder of CardioMEMS, novel treatment for Heart Failure which is now a Class I recommendation of the American Heart Association and American College of Cardiology, randomized trial published in Lancet and Nature; acquired by (St. Jude Medical) Abbott
    • Founder of Angioguard, Inc., novel treatment for stroke which is now a Class I recommendation of the American Heart Association and American Stroke Association, randomized trial published in NEJM; acquired by Johnson & Johnson
    • First investor and director of SMART Therapeutics, novel treatment for stroke which is now a Class I recommendation of the American Heart Association and American Stroke Association; acquired by Boston Scientific
    • Founder of MiRus, commercializing novel, and intellectually protected, molybdenum rhenium (“MoRe”) based alloys for spine and cardiovascular devices. MoRe was the first novel medical alloy cleared by the FDA in more than 3 decades and has over 115 patents globally protecting medical usage of the MoRe alloy.

Having founded multiple companies, Jay fully appreciates founder’s viewpoints and needs. Jay has a broad and deep understanding of the life sciences and the complexities surrounding regulatory and reimbursement pathways. Jay has received FDA approval of multiple novel PMA, HDE, and 510k (including the first ever De Novo 510k) products and leverages this expertise through Mammoth to help founders connect their ultimate commercialization strategy to efficient FDA and CMS pathways. Jay has negotiated multiple license and merger agreements and has direct access to the leadership of many large healthcare companies. Jay has authored over 300 peer reviewed publications, 2 books and over 40 patents. His scientific and entrepreneurial work has been widely recognized. He serves on a number of non-profit boards including Georgia Bio (Chairman), the Global Center for Medical Innovation, TiE, American Heart Association, Southeast Medical Device Association, Beacon College, the Westminster Schools and the Advisory Board on Entrepreneurship for the Yale School of Management.

In addition to his role at Mammoth, Jay is the Chief Executive Officer of MiRus, LLC.

Awards & Recognition

Spine Innovation Award
2018

American Heart Association Honoree
2016

50 Best Doctors in the History of the Cleveland Clinic
2011

Ernst and Young Entrepreneur of the Year (healthcare)
2011

Intel Innovation Award
2011

His procedure for stroke treatment became a Class I recommendation of the American Heart Association and the American College of Cardiology
2011

Ellis Island Medal of Honor
2011

American Heart Association Top Ten Scientific Advances
2003

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